CHAPTER ONE
1.0 Introduction
1.1 Fibrinogen
1.1.1 Fibrinogen Synthesis
1.1.2 Functions of Fibrinogen
CHAPTER TWO
2.0 Types of fibrinogen disorders
2.1 Clinical manifestations
2.1.1 Hypofibrinogenemia
2.1.2 Dysfibrinogenemia
2.2 Laboratory diagnosis
2.2.1 Molecular diagnosis
2.2.2 Dysfibrinogenemia mutations
2.2.3 Prenatal diagnosis
CHAPTER THREE
3.0 Fibrinogen Replacement
3.1 Fresh Frozen Plasma
3.2 Cryoprecipitate
3.3 Fibrinogen Concentrate
3.4 Current understanding of fibrinogen replacement
3.4.1 Preclinical Data
3.4.2 Clinical Data
3.4.2.1 Trauma
3.4.2.2 Perioperative Bleeding
CHAPTER FOUR
4.0 Conclusion and Recommendation
4.1 Conclusion
4.2 Recommendation
References.
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