CHAPTER ONE
1.0Â Â Â Â Introduction
1.1Â Â Â Â Fibrinogen
1.1.1Â Fibrinogen Synthesis
1.1.2Â Functions of Fibrinogen
CHAPTER TWO
2.0Â Â Â Â Types of fibrinogen disorders
2.1Â Â Â Â Clinical manifestations
2.1.1Â Hypofibrinogenemia
2.1.2Â Dysfibrinogenemia
2.2Â Â Â Â Laboratory diagnosis
2.2.1Â Molecular diagnosis
2.2.2Â Dysfibrinogenemia mutations
2.2.3Â Prenatal diagnosis
CHAPTER THREE
3.0Â Â Â Â Fibrinogen Replacement
3.1Â Â Â Â Fresh Frozen Plasma
3.2Â Â Â Â Cryoprecipitate
3.3Â Â Â Â Fibrinogen Concentrate
3.4Â Â Â Â Current understanding of fibrinogen replacement
3.4.1Â Preclinical Data
3.4.2Â Clinical Data
3.4.2.1 Trauma
3.4.2.2 Perioperative Bleeding
CHAPTER FOUR
4.0Â Â Â Â Conclusion and Recommendation
4.1Â Â Â Â Conclusion
4.2Â Â Â Â Recommendation
References.
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