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Anti Hyperlipidemic Potential Of Vitex Donianaethanolextracts On Poloxamer 407 Induced Hyperlipidemic And Normal Rats

TABLE OF CONTENTS

Title Page

Abstract

Table of Contents

 

CHAPTER ONE

1.0       INTRODUCTION

1.1       Statement of Research Problem

1.2       Justification

1.3       Aims of the Study

1.3.1    Specific objectives

 

CHAPTER TWO

2.0       LITERATURE REVIEW

2.1       Vitex Doniana

2.1.1    Habitat/Distribution

2.1.2    Botanical classification

2.1.3    Chemical constituent

2.1.4    Uses

2.2       Polyphenols

2.2.1    Classes

2.2.2    Extraction

2.2.3    Pharmacological action/effect

2.3       Hyperlipidemia

2.3.1    Definition

2.3.2    Classes

2.3.3    Etiology

2.3.4    Diagnosis

2.3.5    Treatment

2.3.6    Experimental model of hyperlipidemia

2.3.7    Hyperlipidemia and liver

2.3.8    Hyperlipidemia and kidney

2.3.9    Hyperlipidemia and hematological parameters

 

CHAPTER THREE

3.0       MATERIALS AND METHODS

3.1       Materials

3.1.1    Plant materials

3.1.2    Chemicals/Reagents

3.1.3    Equipment

3.1.4    Experimental animals

3.2       Methods

3.2.1    Extraction

3.2.2    Phytochemical screening of the plant

3.2.3    In vitro screening of the extracts

3.2.4    In vivo biological activity of extracts

3.2.5 Quantitative phytochemical analysis of the extract

3.2.6Acute toxicity study

3.2.7    Induction of hyperlipidemia

3.2.8    Animal grouping

3.2.9Collection and preparation of samples

3.2.10  Determination of serum lipid profile

3.2.11  Determination of biochemical parameters

3.2.12  Determination of in vivo antioxidant activity

3.2.13 Statistical analysis

 

CHAPTER FOUR

4.0       RESULTS

4.1 Phytochemical Screening of VitexDoniana

4.2In Vitro Screening of the Extracts

4.3 In Vivo Biological Activity of Extracts

4.4Quantitative Phytochemical of EthanolicExtract

4.5Lethal Dosage (LD50) of the Ethanolic Extract

4.6Lipid Profile           and Atherogenic Predictor Indices

4.7Liver Marker Enzymes and Function Parameters

4.8Kidney Function Parameters and Packed Cell Volume

4.9Body Weight

4.10In Vivo Antioxidant Activity

 

CHAPTER FIVE

5.0       DISCUSSION

 

CHAPTER SIX

6.0       SUMMARY, CONCLUSION AND RECOMMENDATION

6.1       Summary

6.2       Conclusion

6.3       Recommendation

REFERENCES

APPENDICES

CHAPTER ONE

1.0 INTRODUCTION

Polyphenols are natural organic chemicals characterized by the presence of large number of phenol structural units (Quideauet al., 2011). The most research-informed and chemistry-aware definition of polyphenol is termed the White–Bate-Smith–Swain– Haslam (WBSSH) definition (Haslam and Cai, 1994) which describes the polyphenol as moderately water-soluble compounds, with molecular weight of 500–4000 Dalton,having more than 12 phenolic hydroxyl groups and with 5–7 aromatic rings per 1000 Da.The number and characteristics of the phenol structures underlie the unique physical, chemical, and biological properties of a particular member of the polyphenol class(Quideau et al., 2011).

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